Blood Cell Aggregation and Screen
نویسندگان
چکیده
RECENT investigations of the conjunctival and nail-bed microcirculation indicate that certain changes in the small blood vessels and the circulating blood are frequently associated with disease. Straight, unkinked arterioles, tortuous veins, and micropools have been observed by Landau and Davis' in subjects with arteriosclerosis. Congestion of the venules and capillaries are seen in diabetes mellitus2-4 Intra-arteriolar aggregation of blood elements5 and capillary ischemia are seen in severe hypertension,6 in severe diabetes,2 and in many systemic acute and chronic illnesses. Some investigators consider intravenular aggregation abnormal, but Knisely,7 Bloch,8 and Davis and associates5 find this misleading and accept only diffuse arteriolar aggregation as evidence of a pathological condition. In most cases, aggregation appears to be accompanied by slowing of the circulation through the capillary bed. Objective measurements of this are lacking. Furthermore, bulk blood viscosity is not changed by the aggregation of blood cells. A detailed study using the capillary-tube viscosity method did not reveal significantly elevated blood viscosity in patients with vascular disease and diabetes mellitus.9 In both conditions aggregation of circulating blood cells is frequently present. The capillary tube used in these studies had an internal diameter of 300 ,u which is sufficiently large to allow free passage of the aggregates, few of which exceed a diameter of 35 /,.
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تاریخ انتشار 2005